The Role Of Gamma-Interferon And Interleukin12 In The Pathogenesis Of Rheumatoid Arthritis Patients In Iraq
DOI:
https://doi.org/10.46966/msjar.v3i4.89Keywords:
RA, IL12,IFN-yAbstract
Background: Objectives: To evaluate the significant importance of IFN-y and IL-12 level in Rheumatoid Arthritis patients. Material and Methods: A serum sample was collected from two groups. The first group was patients with Rheumatoid Arthritis (RA), the Second group was healthy volunteers. serum of this sample used to detect IFN-y and IL12 level was quantified by using ELISA. Result: The level of serum INF-gamma was significantly lower in patients with rheumatoid arthritis in comparison with control group, 54.01 (14.81) versus 62.55 (28.11), respectively (p = 0.006) . The level of serum IL-12 was significantly lower in patients with rheumatoid arthritis in comparison with control group, 8.47 (2.44) versus 132.82 (56.30), respectively (p < 0.001).
Conclusion: On the basis of the current study, the level of serum INF-gamma was significantly lower in patients with rheumatoid arthritis it means have no significant effect on disease susceptibility of patients. This study has found that the level of serum IL-12 was significantly lower in patients with rheumatoid arthritis.
References
Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, Ahmed J.(2018) .Rheumatoid Arthritis: A Brief Overview of the Treatment. Med PrincPract. ;27(6):501-50.
Udalova IA, Mantovani A, Feldmann M.(2016). Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol.;12: 472–485.
Rathore, B. (2018). Rheumatoid Arthritis : an Understanding in the Light of Herbal Medicines. Era’S Journal of Medical Research, 5(1), 45–58 .
Richard MP, Shiva S.(2013). Possible roles of IL 12-family cytokines in rheumatoid arthritis. Nat Rev Rheumatol.; 9:252-6.
Mateen, S., Zafar, A., Moin, S., Khan, A. Q., & Zubair, S. (2016). Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. ClinicaChimica Acta, 455, 161–171.
Paradowska-Gorycka, A., Sowinska, A., Stypińska, B., Haladyj, E., Pawlik, A., Romanowska-Próchnicka, K., &Olesinska, M. (2017). IL-12B Gene Polymorphisms and IL-12 p70 Serum Levels Among Patients with Rheumatoid Arthritis. Scandinavian Journal of Immunology, 85(2), 147– 154.
Al-Rubaye, A. F., Kadhim, M. J., & Hameed, I. H. (2017). Rheumatoid arthritis: history, stages, epidemiology, pathogenesis, diagnosis and treatment. International Journal of Toxicological and Pharmacological Research, 9(02).
Cope, A. P. (2019). 52 - Rheumatoid Arthritis. In Clinical Immunology (Fifth Edit). Elsevier Ltd
Sura Mohammed Jafat,(2021).Thesis Evaluation Prognostic Value of Serum Levels of Soluble Programmed Death Protein 1 (sPD-1) and Soluble Programmed Death-Ligand 1 (sPD-L1) in Patients with Rheumatoid Arthritis: A Cross Sectional Study.University of Kufe,Iraq.
Fathi, H. M., Khairy, N., Gheita, T. A., Battawy, W. A. El, & Taha, R. (2018). Clinical Significance of Periodontitis in Rheumatoid Arthritis Patients: Association with Disease Activity and Functional Status. Journal of Arthritis, 07(02).
Olga M. Koper-Lenkiewicz ,EwaGińdzieńska-Sieśkiewicz , Joanna Kamińska , Anna J. Milewska , Otylia Kowal-Bielecka , Joanna Matowicka-Karna,(2022). Could IL-1β, IL-6, IFN-γ, and sP-selectin serum levels be considered as objective and quantifiable markers of rheumatoid arthritis severity and activity?.Reumatologia ; 60, 1: 16–25.
Wei Zhong, LingZhao, Tao Liu &ZhenyuJiang,(2017). IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide. Scientific Reports | 7:41143 | DOI: 10.1038/srep41143.
Itzel Viridiana Reyes-Pérez1 & Pedro Ernesto Sánchez-Hernández1 & José Francisco Muñoz-Valle2 & Gloria Esther Martínez-Bonilla3 & Trinidad García-Iglesias1 & Verónica González-Díaz 3 & Samuel García-Arellano2 & Sergio Cerpa-Cruz3 & Julissa Polanco-Cruz3 & María Guadalupe Ramírez-Dueñas,(2019). Cytokines (IL-15, IL-21, and IFN-γ) in rheumatoid arthritis: association with positivity to autoantibodies (RF, anti-CCP, anti-MCV, and anti-PADI4) and clinical activity. Journal of Clinical Rheumatology.
Pavlovic V, Dimic A, Milenkovic S, Krtinic D.(2014).Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis. J Res Med Sci;19:18-22.
.Eman H. El-Hakeim,Zeinab A. Abd Elhameed,Fatma H. El Nouby,Mohamed R. Abdel Razek,Omnia Abd El-Moneum, Samar H. Goma,(2020). Association of Interleukin-12B Polymorphism and Serum Level of Interleukin-12 in a Sample of Egyptian Patients with Rheumatoid Arthritis. The Egyptian Journal of Immunology . 27 (1), 19-28.
Tukaj S, Kotlarz A, Jóźwik A, Smolenska Z, Bryl E, Witkovski JM.(2010). Cytokines of the Th1 and Th2 type in sera of rheumatoid arthritis patients; correlations with anti-Hsp40 immune response and diagnostic markers. Acta BiochimPol;57:327-32.
Moktar ER, Hassan AS, Mohamed EF. (2018). polymorphism of interlukin-12B gene and serum level of interlukin-12p70 in rheumatoid arthritis egyptian patients. Clin Med &Diagn.; 8(1):7- 13.
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