Description of Visfatin Adipokine and its Roles on Inflammation and Coronary Heart Disease: A Review Study

Assist. Prof. Dr. Wijdan Rajh Hamza Al-Kraity; Ali Hussein Faisal; Ali Nabeel Khaleel; Mahmoud Tuama Naeaam; Ali Sattar Jabar

doi:10.46966/msjar.v2i1.13

Authors

Assist. Prof. Dr. Wijdan Rajh Hamza Al-Kraity Department Medical Laboratories Techniques, Al-Toosi University College, Iraq
Ali Hussein Faisal Department Medical Laboratories Techniques, Al-Toosi University College, Iraq
Ali Nabeel Khaleel Department Medical Laboratories Techniques, Al-Toosi University College, Iraq
Mahmoud Tuama Naeaam Department Medical Laboratories Techniques, Al-Toosi University College, Iraq
Ali Sattar Jabar Department Medical Laboratories Techniques, Al-Toosi University College, Iraq

DOI:

https://doi.org/10.46966/msjar.v2i1.13

Keywords:

Coronary heart diseases, Visfatin, adipokine, pre-B-cell colony-enhancing factor (PBEF)

Abstract

Coronary heart disease (CHD) is a generic designation for a group of related syndromes resulting from myocardial ischemia – an imbalance between cardiac blood supply (perfusion) and myocardial oxygen demand. Visfatin (VF) is a recently discovered adipokine with different functions, Visfatin is mainly found in visceral adipose tissue and mimics insulin in lowering plasma glucose levels and, Visfatin emerges as a player in the development and progression of atherosclerotic lesions by directly promoting smooth muscle cell proliferation, Aberrant angiogenesis is now considered a feature of the atherogenic process in both coronary and carotid diseases. This adipokine was previously known as a pre-B-cell colony-enhancing factor (PBEF) or Nicotinamide phosphoribosyltransferase (NAmPRTase or Nampt) an enzyme that in humans is encoded by the NAMPT gene and demonstrated to be an intracellular protein with a key enzyme role in nicotinamide adenine dinucleotide (NAD)

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