Cadmium and Zinc in the Aetiology of Inflammatory Arthritis
DOI:
https://doi.org/10.46966/msjar.v7i2.387Keywords:
Cadmium, Zinc, Inflammatory ArthritisAbstract
Background: autoimmune diseases is observed globally, with rheumatic diseases being the most prevalent among them. CD and Zn have their role in autoimmune diseases. Objectives: To investigate the role of cadmium (Cd) and zinc (Zn) in rheumatoid arthritis (RA) pathogenesis by comparing their serum levels in RA patients to healthy controls. Materials and Methods: Biochemical studies were conducted to measure Zn and Cd levels using atomic absorption spectrophotometry and evaluate rheumatoid factor & anti-CCP levels with ELISA. Results: Patient demographics showed no significant differences in sex, age, and smoking status between RA patients (n=50) and controls (n=50). Serum Zn levels were lower in RA patiets (0.66 ± 0.08 μg/L) compared to controls (0.72 ± 0.11 μg/L; p=0.017), Serum Cd levels were higher in RA patients (0.99 ± 0.28 ng/L) compared to controls (0.89 ± 0.21 ng/L; p=0.031). Conclusion: The study suggests an association between elevated serum cadmium and reduced serum zinc levels in RA patients, emphasizing the need for further research on environmental factors and autoimmune disease.
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Copyright (c) 2026 Abbas H. Khalaf , Yasir A. Abdul-Nabi , Qassim H. Khalaf
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