Evaluation of Mitochondrial Dysfunction, Oxidative Stress and Electron Transporters as Biomarkers for The Diagnosis of Autism Spectrum Disorder
DOI:
https://doi.org/10.46966/msjar.v7i2.402Keywords:
autism spectrum disorder, glutathione, glutathione S transferase, GST:GSH ratio, Co enzyme Q10Abstract
Background: Autism spectrum disorder (ASD) is a neuro- developmental disorder commonly seen in children. It is characterized by age inappropriate, impaired social communication and the presence of stereotypic behavior. This disorder is hypothesized to result from cerebral dysfunction arising from a complex interaction between genetic, epigenetic and environmental factors. Biomarkers such as glutathione (GSH), glutathione S transferase (GST), GST: GSH ratio and Co Q10, showing potential for early diagnosis and management of ASD. Objective: to evaluate the effectiveness of GSH, GST, GST:GSH ratio and Co Q10 as novel biomarkers to predict autism at an early stage. Methods: A case- control study which started from November 2023 to June 2024, that involved 77 children’s patients, newly diagnosed with autism. The control group was comprised of 61 age- and sex-matched apparently healthy children, they had no history of autism and any other chronic diseases. Serum samples were analyzed for GSH, GST, GST:GSH ratio and Co Q10 by using enzyme linked immune sorbent assay (ELISA) technique. The statistical package for social sciences (SPSS- 26) was used for data analyses. Results: The study revealed significantly elevated GSH, GST, GST:GSH ratio and Co Q10 levels between the autistic children’s patients and the control group. Conclusions: This study provides a pioneering discovery of the biochemical markers GSH, GST, GST:GSH ratio and Co Q10 in autism, as mitochondrial dysfunction, oxidative stress and electron transporters are the most important chemical causes of autism.
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Copyright (c) 2026 Noor Ahmed Hameed, Shrouk Abd Alrazak Hassan, Hamid Jaddoa Abbass
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