Comparative Expression Genes of GSTM1 and GSTT1 Genes among Benign and Malignant Prostate Cancer
DOI:
https://doi.org/10.46966/msjar.v7i3.435Keywords:
prostate cancer, GSTM1 , GSTT1 genesAbstract
Background: Prostate cancer is one of the malignancies that affects men and significantly contributes to increased mortality rates in men globally. Patients affected with prostate cancer present with either a localized or advanced disease. Objective: The present study aimed to determining the relationship between gene expression of GSTM1 and GSTT1 genes in the sera of patients and compared it with healthy. Materials and methods: A case control study consist of three group included was in this study . The first group involves 50 patients with PC were observation in Al- Amal Oncology Hospital in the period from April 2021 to April 2022 under the supervision of oncology specialists was included in this study. Second group consist of 30 patients. They have benign hyper plaisa (BHP), this group has been collected from urosergical department . Third group was include 20 healthy volunteers (non prostate cancer and non BHP). The RNA extraction from whole blood of both the patients and healthy by using protocol in TransZOl Up Plus RNA kit (Transgen- China) to determining gene expression of GSTM1 and GSTT1 genes in study groups. Results: Results of the present study showed the 60-69 years age group scored highest percentage in benign (56.7%), malignant (54.0%), compared to control (healthy) (50.0%), while >69 years scored least percentage in these groups (3.3%, 14.0%, and 25.0%) respectively with significant different (p<0.05). Additionally, it is found the GSTM1 and GSTT1 genes levels scored highest mean levels in malignant group (8.67±2.17 and 8.80±3.65) and least mean level in healthy (1.00±0.00 and 1.00±0.00) compared to benign group with significant different (p<0.05). Conclusions: We concluded the GSTM1 and GSTT1 genes levels are play major roles in pathogenesis patients with prostate cancer. PCa is high prevalence in elderly population.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Azhar. S.H. Al-Nasralla, Suzan Saadi Hussian, Nihad khalawe Tektook
This work is licensed under a Creative Commons Attribution 4.0 International License.
In submitting the manuscript to the Medical Science Journal for Advance Research, the authors certify that:
- They are authorized by their co-authors to enter into these arrangements.
- The work described has not been formally published before, except in the form of an abstract or as part of a published lecture, review, thesis, or overlay journal.
- That it is not under consideration for publication elsewhere,
- The publication has been approved by the author(s) and by responsible authorities – tacitly or explicitly – of the institutes where the work has been carried out.
- They secure the right to reproduce any material that has already been published or copyrighted elsewhere.
- They agree to the following license and copyright agreement.
License and Copyright Agreement
Authors who publish with Medical Science Journal for Advance Research agree to the following terms:
- Authors retain copyright and grant the Medical Science Journal for Advance Research right of first publication with the work simultaneously licensed under Creative Commons Attribution License (CC BY 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the Medical Science Journal for Advance Research published version of the work (e.g., post it to an institutional repository or edit it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) before and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
