Pre-treatment of Flowers Extract of Abelmoschus manihot Medicus on Ischemia/Reperfusion Renal Injury in Rats

Jinsong O; Cholyong O; Sinhyok Paek; Yongsu Ri; Yongjae Kang; Yongjun Kim; Songchan Han; Hyon-Song Jang

doi:10.46966/msjar.v6i3.309

Pre-treatment of Flowers Extract of Abelmoschus manihot Medicus on Ischemia/Reperfusion Renal Injury in Rats

Authors

Jinsong O Pyongyang University of Medical Sciences, Central District, Pyongyang, Democratic People’s Republic of Korea.
Cholyong O Pyongyang University of Medical Sciences, Central District, Pyongyang, Democratic People’s Republic of Korea.
Sinhyok Paek Pyongyang Medical College, Taedonggang District, Pyongyang, Democratic People’s Republic of Korea.
Yongsu Ri Sinuiju University of Medical Sciences, Pynghwa Dong, Sinyuzu, North Phyongan province, Democratic People’s Republic of Korea.
Yongjae Kang Gyongsong College of Medical technics, Gyongsong country, North Hamgyong province, Democratic People’s Republic of Korea.
Yongjun Kim Pyongyang University of Medical Sciences, Central District, Pyongyang, Democratic People’s Republic of Korea.
Songchan Han Pyongyang University of Medical Sciences, Central District, Pyongyang, Democratic People’s Republic of Korea.
Hyon-Song Jang Kim Il Sung University, Taesong District, Pyongyang, Democratic People’s Republic of Korea.

DOI:

https://doi.org/10.46966/msjar.v6i3.309

Keywords:

Abelmoschus manihot (Linnaeus) Medicus (Malvaceae) (AM), Ischemia/Reperfusion (I/R), Oxidative stress

Abstract

Background and Aim: The purpose of this study is to provide a basic data with the use of flowers extract of Abelmoschus manihot (Linnaeus) Medicus (Malvaceae) (AM) as a herbal agent against renal oxidative stress. Materials and Methods: Pre-treatment effect of flowers extract of AM in rat with renal ischemia/reperfusion(I/R) injury was investigated. Renal I/R injury in rat were induced by clamping of the left and right renal arteries for 45 min followed by 24 h of reperfusion after administration of flowers extract of AM for 30 days. The effect of flowers extract of AM was evaluated through the measurement of renal function and the relevant parameters of oxidative stress. Results: Renal I/R injury led to renal dysfunction as evidenced by higher serum BUN and creatinine along with increase in oxidative stress in renal tissues compared with Sham group. Pre- treatment of flowers extract of AM decreased serum BUN, creatinine, and renal MDA levels, and increased SOD, CAT and GSH-PX activities in the kidney. Conclusion: Collectively, these data indicated that flowers extract of AM could be used as a safe and natural antioxidant for the protection of oxidative stress in kidney.

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Published

2025-09-15

How to Cite

O, J., O, C., Paek, S., Ri, Y., Kang, Y., Kim, Y., Han, S., & Jang, H.-S. (2025). Pre-treatment of Flowers Extract of Abelmoschus manihot Medicus on Ischemia/Reperfusion Renal Injury in Rats. Medical Science Journal for Advance Research, 6(3). https://doi.org/10.46966/msjar.v6i3.309

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Issue

Vol. 6 No. 3 (2025): September, Medical Science Journal for Advance Research

Section

Original Articles

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