The Role of miRNA 23a and Inflammatory Factors in Fertility Disorders in Women with Polycystic Ovary Syndrome: An Integrated Study between Molecular and Metabolic Markers

Abstract

Polycystic ovary syndrome (PCOS) is another significant cause for women to be infertile, which is caused by the failure to ovulate properly, changes in hormone and metabolism. It is also related with molecular disorders, inflammatory responses on reproductive function in this syndrome. The purpose of this study was to explore the functions of miRNA-23a, inflammatory markers and metabolic markers, including AOA and TGF-β in patients with polycystic ovary syndrome who experienced infertility. The purpose of this study was to assess miRNA-23a, inflammatory factors and metabolic markers (TGF β and AOA) in females in the context of fertility disorders such as polycystic ovary syndrome. 90 patients participated in the study and the level of BMI, mannerism TGFB, as well as the level of miRNA-23a and AOA were measured, while assessing the differences and correlations between a group of women patients and the group of healthy women. The mean age was not different between the two groups (25.74 ± 4.85 years, t(88) = -0.168, p = 0.867), BMI, AOA, TGFB, and the miRNA-23a was significantly higher in the women patients than in the healthy group (p = 0.001). Spearman's correlation analyses showed positive and significant correlations between miRNA-23a and BMI (r = 0.337, p = 0.001), TGFB and AOA (r = 0.386, p < 0.001), and between AOA and BMI (r = 0.294, p = 0.005), while the other correlations were not significant (miRNA-23a and TGFB, p = 0.071; miRNA-23a and AOA p = 0.061). The data point to the potential of using molecules such as TGF-β, miRNA-23a, and AOA as biomarkers for evaluating and diagnosing PCOS and further highlight the importance of longitudinal studies in understanding the biological relationships between molecular and metabolic markers and any associated fertility disorders.